This book presents the Fifth International Conference on Safety and Security with IoT (SaSeIoT 2023), which took place Bratislava, Slovakia, October 24-26, 2023. The conference aims to explore not only IoT and its related critical applications but also IoT towards Security and Safety. The conference solicits original and inspiring research contributions from experts, researchers, designers, and practitioners in academia, industry and related fields and provides a common platform to share knowledge, experience and best practices in various domains of IoT.