This book contains all refereed papers that were accepted to the second edition of the Asia-Pacific conference on « Complex Systems Design & Management Asia» (CSD&M Asia 2016) that took place in Singapore from February 24  to February 26, 2016 (Website: http://www.2016.csdm-asia.net/). These proceedings cover the most recent trends in the emerging field of Complex Systems, both from an academic and a professional perspective. A special focus is put on Smart Nations: Designing and Sustaining. The CSD&M Asia 2016 conference is organized under the guidance of the Singapore division of the Center of Excellence on Systems Architecture, Management, Economy and Strategy (CESAMES) – Legal address: C.E.S.A.M.E.S. Singapore – 16 Raffles Quay – #38-03 Hong Leong Building – Singapore 048581 (website : http://www.cesames.net/en – email: contact@cesames.net).