Almost all soybean fields have weed infestations that must be managed by farmers to sustain economic viability. This chapter reviews the integrated weed-management approach, which utilizes the contributions of plant breeding, cultural, mechanical and chemical practices in suppressing weed populations and minimizing the impacts of weeds on yield. After establishing the importance of a diverse weed-management strategy, we discuss how farmers set goals for weed management and the importance of focussing on managing the weed seed bank. Sections 3 and 4 review the wide range of management tactics available, while Section 5 considers interactions between weeds and other pests. Section 6 then discusses the factors that limit the adoption of the integrated weed-management approach.