Weeds reduce sugarcane yield by competing for water, nutrients and light. They may also act as alternative hosts for disease and insect pests and increase production costs and lower land value. Implementation of integrated weed management (IWM) in sugarcane is essential to reduce the negative impact of weeds to economically acceptable levels, and understanding of the critical period of weed control (CPWC) is important so that IWM strategies can be developed to maximize control measures. This chapter deals with an integrated approach involving different methods of effective weed management in sugarcane that can be adopted for sustainable production, involving cultural, mechanical and chemical weed control.